Oncology & Cancer
Cancer biology: Targeting tumors with 'stapled' peptides
(Phys.org) —Designer peptides containing chemically stabilized helices emerge as a potent way to activate anti-tumor proteins inside cells.
Jul 17, 2013
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Page 19 - Agency for Science, Technology and Research (A*STAR), Singapore
Immunology
Monocytes switch roles during sepsis
During the course of the deadly disease sepsis, monocytes—a type of white blood cell that helps the body stave off bacteria and viruses—undergo a profound change, A*STAR researchers show. This discovery will help scientists ...
Jan 27, 2016
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Oncology & Cancer
Mutant genes shown to activate a pathway that leads to overproduction of certain kinds of blood cells
Myeloproliferative neoplasms (MPNs) are blood cancers that cause the bone marrow to produce too many red or white blood cells, or platelets, leading to various complications. There is no known cure for most MPNs.
Oct 21, 2016
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Oncology & Cancer
Modified anticancer drug can simultaneously target tumor sites and show whether or not it is working
Cancer drugs can be modified to specifically target tumor sites to help personalize cancer treatment. And while it is relatively easy to determine if the drugs have been delivered to the correct location, it is more difficult ...
Jul 30, 2014
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Immunology
Protein implicated in lupus promotes disease progression by distinct mechanisms in different immune cells
Patients with systemic lupus erythematosus (SLE) come under attack by their immune system, producing 'autoantibodies' that inflict damage throughout the body. Antibodies normally target foreign proteins, but SLE autoantibodies ...
Mar 13, 2013
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Genetics
The genes behind the guardians of the airways
Dysfunctions in cilia, tiny hair-like structures that protrude from the surface of cells, are responsible for a number of human diseases. However the genes involved in making cilia have remained largely elusive. In the first ...
Aug 27, 2014
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Overweight & Obesity
Maternal health linked to child's risk of obesity
Women's fat levels before and during pregnancy are linked to those of their infants in ways that can vary depending on a mother's ethnicity, a Singapore-based study shows, and highlights the need for nuanced health advice.
Feb 11, 2016
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Oncology & Cancer
Nontoxic hydrogel for breast cancer treatment
A nontoxic hydrogel developed by the A*STAR Institute of Bioengineering and Nanotechnology and IBM Research offers a new way forward for breast cancer therapeutics.
Dec 4, 2013
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Ophthalmology
Fighting blindness with technology
The eye disease glaucoma leads to blindness and has no symptoms in the early stages, earning it the nickname "silent thief of sight". Regular eye examinations are essential for early detection and diagnosis of such eye diseases. ...
Jul 11, 2013
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Genetics
Cellular 'stress sensor' that also modulates metabolism could offer therapeutic target for diabetes
An organelle called the endoplasmic reticulum (ER) helps to process newly synthesized proteins destined for delivery to the cell membrane. When the ER becomes overloaded and begins to accumulate poorly folded proteins, an ...
Jul 31, 2013
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