Researchers at the Buck Institute have found a sensor for the reactive molecules linked to diabetic complications, providing a pathway to study many of the ravages of a disease that affects 29 million people in the US. The ...
Oct 20, 2016
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Senescent cells, which stop dividing under stress, are long- recognized drivers of multiple diseases of aging. Mouse studies have shown that targeted removal of these cells and the inflammatory factors they secrete, known ...
Jan 16, 2020
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345
A compound that extends lifespan in a tiny nematode worm slows bone loss in aging mice. That surprising result comes from a longitudinal and functional study of 700 aging mice at the Buck Institute, a project that provides ...
Jan 26, 2021
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Research from the Buck Institute and Stanford University suggests that chronic viral infections have a profound and lasting impact on the human immune system in ways that are similar to those seen during aging. Results are ...
Mar 29, 2021
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187
While newly approved drugs for Alzheimer's show some promise for slowing the memory-robbing disease, the current treatments fall far short of being effective at regaining memory. What is needed are more treatment options ...
Feb 1, 2024
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Systemic clearing of senescent astrocytes prevents Parkinson's neuropathology and associated symptoms in a mouse model of sporadic disease, the type implicated in 95% of human cases. Publishing in Cell Reports, researchers ...
Jan 23, 2018
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217
People overeat and become overweight for a variety of reasons. The fact that flavorful high-calorie food is often available nearly everywhere at any time doesn't help. Buck researchers have determined for the first time why ...
Oct 16, 2023
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42
While the role of the blood-brain barrier has long been appreciated for its ability to maintain precise control over what molecules can enter the nervous system, very little is known about how the cells that form the barrier ...
Aug 15, 2022
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66
Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process.
Nov 13, 2023
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72
Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Publishing in the September ...
Sep 24, 2019
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