Cells that become senescent irrevocably stop dividing under stress, spewing out a mix of inflammatory proteins that lead to chronic inflammation as more and more of the cells accumulate over time. Publishing in the September ...
Sep 24, 2019
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109
The amyloid dye Thioflavin T emerged as the superstar when age researchers in three independent laboratories tested ten already-promising pro-longevity chemicals across a range of distinctive strains and species of tiny nematode ...
Feb 21, 2017
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38
The immune system protects us from infections, harmful substances and problematic changes in our own cells. Traditional research posits that parts of invading pathogens or cells sound the alarm, but accumulating evidence ...
Aug 16, 2022
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75
Buck Institute faculty Judith Campisi, PhD, says age researchers need to stop thinking of cellular senescence, now accepted as an important driver of aging, as a single phenotype that stems from genotoxic stress. Research ...
Dec 10, 2015
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145
Adult stem cells replenish dying cells and regenerate damaged tissues throughout our lifetime. We lose many of those stem cells, along with their regenerative capacity, as we age. Working in flies and mice, researchers at ...
Dec 7, 2017
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149
A woman's fertility normally decreases by her late 30s with reproductive function eventually ceasing at menopause. It is known that a small molecule called nicotinamide adenine dinucleotide (NAD+) plays a critical role in ...
Oct 18, 2023
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41
Humans lose brain volume as they age, at an estimated rate of 5% per decade after age 40. But that estimate obscures the role that individual physiology plays in regards to functional brain aging.
Dec 6, 2022
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107
Older mice who are surgically joined with young mice in order to share a common bloodstream get stronger and healthier, making parabiosis one of the hottest topics in age research. Publishing in Nature Metabolism, researchers ...
Jan 15, 2019
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28
A study from the Buck Institute and UCLA offers an explanation for why a particular genetic form (allele) of apolipoprotein E (ApoE) poses the most significant genetic risk for Alzheimer's disease. Publishing on January 20th ...
Jan 19, 2016
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245
Dietary restriction is arguably the most promising non-genetic method of extending lifespan and healthspan in many model organisms, including mammals. While researchers scramble to develop interventions that would mimic the ...
Sep 22, 2021
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