A key enzyme in sugar metabolism is inactivated particularly easily and efficiently by oxidative stress. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have now shown that with this ...
Apr 6, 2023
0
51
With the combination of the drugs Venetoclax and 5-Azacitidine, a new, effective and more tolerable alternative to chemotherapy for the treatment of AML has been available for several years. But for some patients, the drug ...
Mar 16, 2023
0
1
Scientists from German Cancer Research Center (DKFZ), together with colleagues from Germany, Israel, and the U.S., have found that the gut microbiome may modulate the efficacy of CAR-T cellular immunotherapy CAR-T cells in ...
Mar 13, 2023
0
71
The behavioral disorders observed in autism are associated with a multitude of genetic alterations. Scientists from the Hector Institute for Translational Brain Research (HITBR) have now found another molecular cause for ...
Feb 13, 2023
0
136
In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers led by scientists from the DKFZ-Hector Cancer Institute at the University Medical Center Mannheim and ...
Dec 20, 2022
0
31
During infections, the hematopoietic system switches from normal to emergency mode. This improves the defense against pathogens. Scientists at the German Cancer Research Center have now found an epigenetic switch in blood ...
Dec 9, 2022
0
38
Why do metastases often only appear after the original tumor has been surgically removed? Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim Medical Faculty of Heidelberg ...
Oct 26, 2022
0
40
Two proteins ensure that cells can take up iron when needed. If both control proteins are switched off in mice, the animals develop severe anemia, as expected. At the same time, surprisingly, a cell type of the innate immune ...
Oct 7, 2022
0
67
Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food". Building on genetic screens, an international team ...
Sep 9, 2022
0
90
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Hebrew University in Jerusalem have identified in mice the cell of origin of combined liver/biliary duct carcinomas, a rare ...
Aug 19, 2022
0
46
