Gladstone Institutes

Alzheimer's disease & dementia

Predicting Alzheimer's disease-like memory loss before it strikes

For a person with Alzheimer's disease, there's no turning back the clock. By the time she begins to experience memory loss and other worrisome signs, cognitive decline has already set in. And decades of clinical trials have ...

Genetics

A new framework to study congenital heart defects

Each year, 9 months of dreams and anticipation shared by millions of parents-to-be turn to despair and fright when learning their child is born with a birth defect; an often-devastating event affecting one out of 20 children ...

Alzheimer's disease & dementia

A new culprit of cognitive decline in Alzheimer's disease

It has long been known that patients with Alzheimer's disease have abnormalities in the vast network of blood vessels in the brain. Some of these alterations may also contribute to age-related cognitive decline in people ...

Medical research

Scientists uncover new gatekeeper function of anti-aging molecule

The protein klotho has been shown to promote longevity and counteract aging-related impairments. Having more klotho seems to allow for longer and healthier lives, whereas a depletion of this molecule accelerates aging and ...

Immunology

New immunotherapy targeting blood-clotting protein

Normally, the blood protein fibrin does not enter the brain. But in several neurological disorders, the blood-brain barrier—which keeps large molecules in the blood from entering the brain—becomes abnormally permeable, ...

Cardiology

Can a common heart condition cause sudden death?

About one person out of 500 has a heart condition known as hypertrophic cardiomyopathy (HCM). This condition causes thickening of the heart muscle and results in defects in the heart's electrical system. Under conditions ...

Diseases, Conditions, Syndromes

Scientists find a new way to attack herpesviruses

Human cytomegalovirus is a leading cause of birth defects and transplant failures. As it's evolved over time, this virus from the herpes family has found a way to bypass the body's defense mechanisms that usually guards against ...

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