Hubrecht Institute

The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park 'De Uithof'. Since 2008, the Hubrecht is affiliated with the UMC Utrecht.


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Optimization of human small intestinal organoids

Researchers from the Organoid group (formerly the Clevers group) have improved human small intestinal organoids—miniature versions of the small intestine. This will help them to better study the functioning of the small ...


New gene identified in arrhythmogenic cardiomyopathy

Researchers from the group of Eva van Rooij at the Hubrecht Institute have used advanced sequencing technology to better understand the heart disease arrhythmogenic cardiomyopathy, in which heart muscle tissue is replaced ...


Intestinal cells change functions during their lives

Intestinal cells can change specializations during their lives. The BMP signaling pathway—an important communication mechanism between cells—appears to be the driver of these changes. That is what scientists from the ...

Oncology & Cancer

First patient-derived organoid model for cervical cancer

Researchers from the group of Hans Clevers (Hubrecht Institute) developed the first patient-derived organoid model for cervical cancer. They also modeled the healthy human cervix using organoids. In close collaboration with ...

Medical research

Crying human tear glands grown in the lab

Researchers from the lab of Hans Clevers (Hubrecht Institute) and the UMC Utrecht used organoid technology to grow miniature human tear glands that actually cry. The organoids serve as a model to study how certain cells in ...

Medical research

Molecular landscape of the hematopoietic stem cell cradle

Researchers from the group of Catherine Robin at the Hubrecht Institute have characterized the molecular landscape of the aorta that supports the generation of the first hematopoietic stem cells (HSCs) in the embryo. HSCs ...

Oncology & Cancer

Studying the development of ovarian cancer with organoids

High-grade serous ovarian cancer is the most common type of ovarian cancer, and has the lowest rate of survival. It is often only diagnosed when it has already spread within the pelvis and abdomen, making it harder to treat. ...

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