Dravet syndrome is a rare and severe form of epilepsy caused primarily by inherited loss-of-function mutations in a gene called SCN1A. This gene encodes a sodium ion channel known as Nav1.1 and is required for the proper ...
Sep 20, 2013
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The gastrointestinal tract is lined with intestinal epithelial cells (IECs) that maintain gut health by keeping bacteria and pro-inflammatory immune cells from infiltrating gut tissues. Now, a team of researchers in Japan ...
Oct 14, 2011
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During brain development, nerve fibers grow and extend to form brain circuits. This growth is guided by molecular cues (Fig. 1), but exactly how these cues guide axon extension has been unclear. Takuro Tojima and colleagues ...
Aug 1, 2014
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A new study by researchers at the RIKEN Center for Integrative Medical Science in Japan reports differences in blood cell mutations between Japanese and European populations. The study found that these pre-clinical mutations ...
Jun 24, 2020
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Researchers in Japan have created a genetic test that will help doctors diagnose prostate cancer. When given together with testing for prostate specific antigen (PSA), a widely used diagnostic biomarker for prostate cancer, ...
Feb 8, 2013
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Sufferers of schizophrenia experience a broad gamut of symptoms, including hallucinations and delusions as well as disorientation and problems with learning and memory. This diversity of neurological deficits has made schizophrenia ...
Nov 29, 2013
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Like broccoli and ice cream on a toddler's plate, the brain also keeps nice and nasty information in separate places. Within the amygdala, an important memory center in the brain, pleasant experiences, tastes, and smells ...
Oct 17, 2016
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The formation and retrieval of memories allows all kinds of organisms, including humans, to learn and thrive in their environment. Yet our memories are not always accurate, and mistaken remembrances can have important consequences, ...
Sep 13, 2013
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Specialized immune cells called T cells can recognize threats and induce immune responses through T cell receptors (TCRs), but these receptors do not act alone. Multiple receptors gather together at the cell surface to cooperatively ...
Oct 7, 2011
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(Medical Xpress) -- A large, RIKEN-led, international team of genome researchers has found nine new associations of gene regions or loci with the autoimmune disease rheumatoid arthritis. The loci, found in ethnically Japanese ...
Aug 17, 2012
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