Sanford Burnham Prebys Medical Discovery Institute

Diseases, Conditions, Syndromes

Path to deadly sepsis varies by bacterial infection

Sepsis remains a common and deadly condition that occurs when the body reacts to an infection in the bloodstream. Scientists know little about the early stages of the condition; however, physicians must act fast. Every hour ...

Inflammatory disorders

Solving the gut inflammation puzzle

Inflammatory bowel disease (IBD), an umbrella term for a number of gut disorders—including ulcerative colitis and Crohn's disease—remains a clinical challenge. Current treatments don't work for all patients, and many ...

Medical research

Mannose's unexpected effects on the microbiome and weight gain

Scientists continue to unravel links between body weight and the gut microbiome. Now, researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP) report an unexpected finding: mice fed a fatty diet and mannose, ...

Diseases, Conditions, Syndromes

An old drug finds new purpose against retinal neovascularization

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have found that the anti-malaria drug amodiaquine inhibits the apelin receptor protein, which helps drive the vascularization behind diabetic retinopathy, ...

Oncology & Cancer

Shedding light on 100-year-old cancer mystery

For almost a century, scientists have observed a strange behavior in cancer cells: They prefer a less-efficient pathway to produce energy. While normal cells utilize aerobic glycolysis to use glucose to produce 36 energy-storing ...

Medical research

Sarcolipin tricks muscle cells into using more energy, burning fat

Ever wonder why you burn fat and heat up when you exercise or shiver? Now, researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have shown that sarcolipin, a small peptide only found in muscles, increases ...

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