Sanford Burnham Prebys Medical Discovery Institute

Neuroscience

ALS research reveals new treatment approach

On June 2, 1941, at the age of 37, baseball player Lou Gehrig succumbed to amyotrophic lateral sclerosis (ALS), a progressive muscle degeneration disease. Today, nearly 80 years following his death, scientists are still searching ...

Oncology & Cancer

How prostate cancer becomes treatment resistant

The development of effective anti-androgen therapies for prostate cancer is a major scientific advance. However, some men who receive these targeted treatments are more likely to develop a deadly treatment-resistant prostate ...

Oncology & Cancer

Targeted treatment shrinks deadly pediatric brain tumors

Chemotherapy and radiation are effective cancer treatments because they kill rapidly dividing cells, including tumor cells. But for children—whose tiny bodies are still growing—these treatments can cause lifelong damage. ...

Oncology & Cancer

Nutritional cues regulate pancreatic tumor's 'cell drinking'

Desperate for nutrients, rapidly growing pancreatic tumors resort to scavenging "fuel" through an alternative supply route, called macropinocytosis. Scientists are hopeful that blocking this process, often described as "cellular ...

Medical research

Mannose's unexpected effects on the microbiome and weight gain

Scientists continue to unravel links between body weight and the gut microbiome. Now, researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP) report an unexpected finding: mice fed a fatty diet and mannose, ...

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