In 2008, the Telomeres and Telomerase Group led by Maria A. Blasco at the Spanish National Cancer Research Centre (CNIO) was one of the first to discover TERRAs, long non-coding telomeric RNAs that are transcribed from telomeres ...
Apr 26, 2018
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The pancreas, located behind the stomach, manages the energy supply in our body. It does so by secreting proteins (enzymes) responsible for glucose—the body's main fuel—that reach other organs when required and in the ...
Jul 21, 2023
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Cohesin is a protein complex that is essential for chromosome segregation in dividing cells. Recent evidence suggests that it also plays an important role in 3-D genome architecture, which folds like origami and regulates ...
Jun 18, 2019
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One of the most frequent problems when treating cancer is that the tumors develop resistance to therapies; at that point, treatments cease to be effective at stopping tumor growth. This is especially relevant in patients ...
Feb 27, 2020
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Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have described the mechanisms, unknown to date, involved in maintaining embryonic stem cells in the best ...
Mar 25, 2021
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Nearly half of all patients with brain metastasis experience cognitive impairment. Until now, it was thought that this was due to the physical presence of the tumor pressing on neural tissue. But this "mass effect" hypothesis ...
Aug 30, 2023
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In mammals, the liver detects the body's energy demand at any given moment and mobilizes nutrient reserves to meet it. It is a vital function that is subdivided into multiple tasks: from releasing glucose into the blood when ...
Mar 18, 2024
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Identifying and prioritizing treatment options based on a patient's profile of genetic alterations is a major challenge in personalized cancer medicine. A new data-driven approach called PanDrugs can help to this end. This ...
Jun 1, 2018
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Negative results and findings in science are perhaps less newsworthy, but they are no less important. In fact, negative results in a cancer study have demonstrated that a possible new therapeutic pathway against idiopathic ...
Aug 21, 2018
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Investigation of biological mechanisms in urothelial tissue, one of the three types of tissue that make up the urinary system, has always been very limited due to the lack of technologies that allow working with stable and ...
Oct 7, 2019
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