Autoimmune liver diseases (ALDs), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), are complex conditions involving the liver's immune-mediated damage. These ...
Jul 15, 2024
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Cholestatic liver diseases (CLDs) are a group of disorders characterized by the impairment of bile formation, secretion, or excretion. This impairment leads to bile acid accumulation in the liver, causing liver biochemical ...
Jul 12, 2024
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Liver diseases are commonly diagnosed using serum enzyme assays, particularly for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), and 5'-nucleotidase ...
Jul 2, 2024
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A clinical trial led by Birmingham researchers investigated targeting a molecule causing liver inflammation and fibrosis to treat patients with Primary sclerosing cholangitis (PSC)—a debilitating liver disease for which ...
May 14, 2024
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Accelerated aging was more common in recent birth cohorts and was associated with increased incidence of early-onset solid tumors, according to research presented at the American Association for Cancer Research (AACR) Annual ...
Apr 8, 2024
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A team of UC Davis Health clinicians and data scientists has developed a machine-learning model to better predict which patients are at greater risk of developing a common type of liver cancer, hepatocellular carcinoma (HCC).
Feb 29, 2024
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For patients with primary biliary cholangitis, more receiving the peroxisome proliferator-activated receptor delta (PPARδ) agonist seladelpar have a biochemical response and alkaline phosphatase normalization, according ...
Feb 27, 2024
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Researchers from Niigata University and a University of Pennsylvania team have identified a novel macrolide–DEL-1 axis that helps in bone regeneration and new bone formation. This finding may lead to the development of ...
Jan 25, 2024
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An international clinical trial involving UC Davis Health suggests the investigational drug Elafibranor is a potential novel treatment for patients with the rare, autoimmune disease primary biliary cholangitis. Results from ...
Nov 16, 2023
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Centenarians, once considered rare, have become commonplace. Indeed, they are the fastest-growing demographic group of the world's population, with numbers roughly doubling every ten years since the 1970s.
Oct 9, 2023
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