Diseases, Conditions, Syndromes

Using crystals to unpack how viruses work

Researchers at Cardiff University have used X-ray crystallography and computer simulation to get a closer look at how viruses bind cells and cause infection.

Oncology & Cancer

Engineering a cancer-fighting virus

Hokkaido University researchers have engineered a virus that selectively targets and kills cancer cells. The virus, called dl355, has an even stronger anticancer effect than another engineered virus currently used in clinical ...

Diseases, Conditions, Syndromes

Science Says: Fatal outbreak germ a threat to frail patients

A common virus blamed for a deadly outbreak at a New Jersey children's rehabilitation center usually poses little risk for healthy people but can lead to dangerous pneumonia in already frail patients.

Diseases, Conditions, Syndromes

What is the virus that has killed 7 children in New Jersey?

(HealthDay)—New Jersey health officials on Wednesday confirmed the deaths of seven children following infection with an adenovirus—a member of the same viral family that causes the common cold.

Genetics

CRISPR enhances gene therapy to fight inherited diseases

Gene therapy has shown promise in treating inherited genetic diseases, but a major issue that has frustrated scientists remains: Replacing a "bad" gene with a healthy one often is a short-lived fix. Typically, the healthy ...

Medical research

Delivering therapy beyond the blood-brain barrier

Brain diseases are particularly challenging to treat. Every substance that has to be delivered to the brain needs to overcome several obstacles, such as the blood-brain barrier—a system that prevents potentially dangerous ...

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Adenoviridae

Adenoviruses are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) icosahedral viruses composed of a nucleocapsid and a double-stranded linear DNA genome. There are 57 described serotypes in humans, which are responsible for 5–10% of upper respiratory infections in children, and many infections in adults as well.

Viruses of the family Adenoviridae infect various species of vertebrates, including humans. Adenoviruses were first isolated in 1953 from human adenoids. They are classified as group I under the Baltimore classification scheme, meaning their genomes consist of double stranded DNA.

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