Diabetes

PPAR-gamma antagonist imatinib improves insulin sensitivity

(HealthDay)—Imatinib (Gleevec) blocks CDK5-mediated peroxisome proliferator-activated receptor γ (PPARγ) phosphorylation as an antagonist ligand, improving insulin sensitivity and promoting browning of white adipose tissue, ...

Oncology & Cancer

Why prostate cancer is more aggressive in obese patients

Obesity has direct consequences on health and is associated with the onset of aggressive cancers, but the mechanisms underlying this phenomenon are little known. Researchers from the Institut de Pharmacologie et Biologie ...

Overweight & Obesity

Activating beige fat in humans could combat obesity

The body's ability to harness heat production by converting white fat cells, which store calories, into beige fat cells, which burn energy, could help fight obesity, according to researchers at Georgia State University.

Overweight & Obesity

Stored fat fights against the body's attempts to lose weight

The fatter we are, the more our body appears to produce a protein that inhibits our ability to burn fat, suggests new research published in the journal Nature Communications. The findings may have implications for the treatment ...

Medical research

How depleting the gut microbiota protects from obesity

In the past few years, research on gut microbiota (that is, all microorganisms, mainly bacteria, inhabiting our gut) has started to unravel its tremendous role in our body, and how it symbiotically affects the functioning ...

Surgery

Higher incidence of paradoxical adipose hyperplasia reported

(HealthDay)—The incidence of paradoxical adipose hyperplasia (PAH) following cryolipolysis may be higher than previously described, according to a report published in the August issue of Lasers in Surgery and Medicine.

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