Improved metabolic profile after roux-en-Y gastric bypass

Improved metabolic profile after roux-en-Y gastric bypass
Roux-en-Y gastric bypass is associated with attenuated markers of oxidative stress in subcutaneous adipose tissue, according to a study published recently in Diabetes.

(HealthDay)—Roux-en-Y gastric bypass (RYGB) is associated with attenuated markers of oxidative stress in subcutaneous adipose tissue, according to a study published recently in Diabetes.

X. Julia Xu, Ph.D., from the Boston University School of Medicine, and colleagues examined how AMP-activated protein kinase (AMPK) activity, oxidative stress, inflammation, and are affected by RYGB surgery. They studied 11 patients immediately before and three months after surgery.

The researchers found that AMPK activity increased 3.5-fold after surgery, and decreased by 50 percent in . There was also an 80 percent reduction in malonyl-CoA levels. There were improvements in both (BMI) and insulin sensitivity, and an increase in circulating high molecular weight (HMW) adiponectin, while fasting plasma insulin levels decreased. The expression of inflammatory markers was unchanged postoperatively in subcutaneous adipose tissue, although there was a 50 percent decrease in plasma C-reactive protein.

"We demonstrated that three months postoperatively, there is a substantial improvement in the patients' metabolic profile as assessed by changes in body weight, BMI, circulating HMW adiponectin, insulin sensitivity, and increased adipose tissue AMPK phosphorylation/activation," the authors write.


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RYGB cuts markers of oxidative stress in subcutaneous tissue

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Citation: Improved metabolic profile after roux-en-Y gastric bypass (2015, July 24) retrieved 18 October 2019 from https://medicalxpress.com/news/2015-07-metabolic-profile-roux-en-y-gastric-bypass.html
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