Genetics

Researchers refine understanding of fetal hemoglobin regulation

Researchers at Children's Hospital of Philadelphia (CHOP) have discovered a new part of the regulatory cascade responsible for silencing fetal hemoglobin in adult cells. The findings, published today in Nature Genetics, refine ...

Diabetes

Lower HbA1c linked to better diabetes-specific HRQoL in youth

(HealthDay)—For children, teens, and young adults with type 1 diabetes mellitus (T1DM), hemoglobin A1c (HbA1c) is associated with better diabetes-specific health-related quality of life (D-HRQoL), according to a study published ...

Diabetes

Glycemic control worse than thought in adults with T1DM

(HealthDay)—For adults with type 1 diabetes, glycemic control may be worse than previously thought, and rates of all complications increase with increasing hemoglobin A1c (HbA1c), according to a study published online Sept. ...

Diabetes

2019 screening guidelines would label more as T2DM cases

(HealthDay)—Adopting the 2019 Endocrine Society guidelines for diabetes screening would substantially increase the number of older adults classified as having type 2 diabetes but would likely offer limited benefits, according ...

Medical research

Forcing chromosomes into loops may switch off sickle cell disease

Scientists have altered key biological events in red blood cells, causing the cells to produce a form of hemoglobin normally absent after the newborn period. Because this hemoglobin is not affected by the inherited gene mutation ...

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