Researchers at Children's Hospital of Philadelphia (CHOP) have discovered a new part of the regulatory cascade responsible for silencing fetal hemoglobin in adult cells. The findings, published today in Nature Genetics, refine ...
Aug 8, 2022
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The genetic blood disorders sickle cell disease and beta-thalassemia are caused by errors in the genes for hemoglobin, a protein in red blood cells that carries oxygen from the lungs to tissues throughout the body. In utero, ...
May 26, 2022
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An international team of scientists led by researchers at St. Jude Children's Research Hospital has found a way to use CRISPR gene editing to help fix sickle cell disease and beta-thalassemia in blood cells isolated from ...
Aug 15, 2016
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Not long after birth, human babies transition from producing blood containing oxygen-rich fetal hemoglobin to blood bearing the adult hemoglobin protein. For children with sickle cell disease, the transition from the fetal ...
Oct 13, 2011
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(HealthDay)—For older adults with diabetes hospitalized for common medical conditions, discharge with intensified diabetes medications increases short-term risk for severe hypoglycemia but does not reduce severe hyperglycemia ...
Oct 21, 2021
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Researchers at Children's Hospital of Philadelphia (CHOP) have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production ...
Jun 1, 2021
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(HealthDay)—Adopting the 2019 Endocrine Society guidelines for diabetes screening would substantially increase the number of older adults classified as having type 2 diabetes but would likely offer limited benefits, according ...
Jun 19, 2020
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"Mothering" is synonymous with "nurturing," probably because moms start providing for their kids even before they're born.
May 5, 2020
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A pilot gene therapy treatment for sickle cell disease, restoring patients' ability to make fetal hemoglobin, has produced good results in the first three patients to receive it. Investigators at Boston Children's Hospital ...
Jan 10, 2020
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(HealthDay)—For adults with type 1 diabetes, glycemic control may be worse than previously thought, and rates of all complications increase with increasing hemoglobin A1c (HbA1c), according to a study published online Sept. ...
Oct 1, 2019
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