Alzheimer's disease & dementia

'Chaperone' compounds offer new approach to Alzheimer's treatment

A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer's disease involving the so-called ...

Alzheimer's disease & dementia

New mouse model could revolutionize research in Alzheimer's disease

In a study published today in Nature Neuroscience, a group of researchers led by Takaomi Saido of the RIKEN Brain Science Institute in Japan have reported the creation of two new mouse models of Alzheimer's disease that may ...

Alzheimer's disease & dementia

Enzyme BACE1 may be important in predicting onset of Alzheimer disease

The critical enzyme beta-secretase1 (BACE1) is known to be elevated in brains with sporadic Alzheimer disease (AD). Scientists have now found increased levels of BACE1 in brains with mild cognitive impairment (MCI), suggesting ...

Alzheimer's disease & dementia

Understanding a protein's role in familial Alzheimer's disease

Researchers at the University of California, San Diego School of Medicine have used genetic engineering of human induced pluripotent stem cells to specifically and precisely parse the roles of a key mutated protein in causing ...

Alzheimer's disease & dementia

Major Alzheimer's risk factor linked to red wine target

The major genetic risk factor for Alzheimer's disease (AD), present in about two-thirds of people who develop the disease, is ApoE4, the cholesterol-carrying protein that about a quarter of us are born with. But one of the ...

Alzheimer's disease & dementia

Alzheimer's disease protein controls movement in mice

Researchers in Berlin and Munich, Germany and Oxford, United Kingdom, have revealed that a protein well known for its role in Alzheimer's disease controls spindle development in muscle and leads to impaired movement in mice ...

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