A new study indicates that severity of amyloid deposition in the brain—not just age—may be key to determining who will benefit from new anti-amyloid therapies to delay the progression of Alzheimer's disease.
Dec 22, 2023
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Despite affecting millions worldwide, Alzheimer's disease (AD) has long lacked effective treatments due to a fundamental inadequacy of our understanding of its etiology and pathogenesis. The absence of an integrative theory ...
Dec 18, 2023
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Researchers led by the ESRF, the European Synchrotron, have found that amyloid oligomers play a role in speeding up mitochondrial energetics during the early stages of Alzheimer's, in contrast to what has been previously ...
Dec 14, 2023
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Alzheimer's disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life. But one member of that family evaded what had seemed would be fate: Despite inheriting the ...
Dec 11, 2023
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Scientists believe a buildup of the brain protein amyloid beta plays a key role in the death of neurons, which can lead to Alzheimer's disease. Although most people develop some amyloid beta brain proteins as they age, researchers ...
Dec 11, 2023
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Alzheimer's disease (AD) is a debilitating incurable disease that affects millions of patients worldwide. Deposits of amyloid beta (Aβ) amyloid in the brain is key to AD pathology at early stages. Apolipoprotein E (apoE) ...
Dec 7, 2023
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Indiana University researchers are collaborating on a novel approach to use neuroimaging and network modeling tools—previously developed to analyze the brains of patients in the clinic—to investigate Alzheimer's disease ...
Nov 30, 2023
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New insights into the pathogenesis of Alzheimer's disease could unlock novel therapeutic approaches and help to prevent the disease. A study led by Professors Marcus Grimm and Tobias Hartmann at the Rhineland Campus of the ...
Nov 28, 2023
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Common neuropsychiatric symptoms that doctors see in Alzheimer's disease patients originate from brain inflammation rather than amyloid and tau proteins, report University of Pittsburgh School of Medicine researchers in JAMA ...
Nov 27, 2023
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In people with Alzheimer's disease (AD), the epigenetic regulator HDAC6 (histone deacetylase 6), which controls many biological processes, is significantly overexpressed in the brain.
Nov 27, 2023
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