A new Northwestern Medicine study has uncovered previously unidentified intracellular mechanisms in the peripheral nervous system that cause Charcot–Marie–Tooth Type 2B disease, a rare congenital disorder that causes ...
Nov 16, 2023
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A new study by Professor Toshio Ohshima of Waseda University has found that the inhibition of phosphorylation of collapsing response mediator protein 2 (CRMP2), a microtubule-binding protein, suppresses degeneration of nerve ...
May 21, 2019
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Neurological diseases often begin with an inflammatory process and the degradation of the myelin layer, which surrounds the nerve fibers (axons) like a protective insulating layer. This is usually followed by damage to the ...
Sep 28, 2022
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The permanent neurological deficits of multiple sclerosis patients largely depend on the extent of degeneration of long nerve fibers. The latter is initiated by ruptures in the cell membrane and the resulting influx of calcium ...
Jan 25, 2019
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Neuregulin 1 (NRG1) is a pleiotropic factor characterized by the existence of numerous isoforms arising from alternative splicing of exons that confer to the protein deeply different characteristics. NRG1 plays an important ...
Jul 25, 2014
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Axons connect neurons with each other to form the neural networks that underpin the vital functions of perception, motility, cognition, and memory. In many neurodegenerative disorders, from traumatic injury or toxic damage ...
Jan 22, 2015
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A major contributor to most neurological diseases is the degeneration of a wire-like part of nerve cells called an axon, which electrically transmits information from one neuron to another. The molecular programs underlying ...
Mar 9, 2017
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(HealthDay)—Patients with type 2 diabetes have reduced endothelium-dependent vasodilation, regardless of the presence of polyneuropathy, according to a study published online Feb. 15 in Diabetes Care.
Feb 21, 2017
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