Immunology

Smoking may cause inflammatory bowel disease

A new study shows a direct effect of cigarette smoke on intestinal inflammation for the first time. Researchers in South Korea report that exposing mice to cigarette smoke results in colitis, an inflammation of the colon ...

Medical research

Gut response to fluid flow

Flow of fluids through the gut, such as milk from an infant's diet, generates a shear stress on cells lining the intestine. Ken Lau, Ph.D., and colleagues have demonstrated that microvilli – finger-like membrane protrusions ...

Oncology & Cancer

New bowel cancer drug target discovered

Researchers at the Francis Crick Institute have discovered a new drug target for bowel cancer that is specific to tumour cells and therefore less toxic than conventional therapies.

Immunology

Lower levels of antioxidants may lessen damage from colitis

A new study finds that lowering the levels of an antioxidant in the colon has an unexpectedly positive effect on gastrointestinal (GI) inflammation. The paper is published ahead of print in the American Journal of Physiology—Gastrointestinal ...

Immunology

Drug targeting could aid immune diseases

A new technique that targets drugs to specific cells could lead to improved therapies for diseases caused by an overactive immune response. The approach could help people affected by conditions such as arthritis and inflammatory ...

Medical research

The colons of patients with IBS react differently to bacteria

The intestinal barrier of patients with the gastrointestinal disease IBS allows bacteria to pass more freely than in healthy people, according to a study led by researchers at Linköping University in Sweden. The study, published ...

Oncology & Cancer

Bowel cancer study reveals impact of mutations on protein networks

For the first time, scientists have completed a detailed study of many of the proteins in bowel cancer cells. Scientists from the Wellcome Trust Sanger Institute investigated the role proteins play in predicting how common ...

Immunology

Scientists make critical insights into T-cell development

Mutations in the gene encoding the enzyme protein tyrosine phosphatase N2 (PTPN2) have been associated with the development of autoimmune disease including Type 1 diabetes, Crohn's Disease and rheumatoid arthritis.

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