Oncology & Cancer

Most women who have double mastectomy don't need it, study finds

About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so despite a very low risk of facing cancer in the healthy breast, new research from the University of Michigan Comprehensive ...

Oncology & Cancer

Managing ovarian cancer risk in women with BRCA1/2 genetic variants

BRCA1 and BRCA2 genetic variants are a clinically important risk factor for the development of ovarian and breast cancer, and women who carry these variants have a lifetime risk of ovarian cancer of 39%-44% and 11%-17%, respectively.

Oncology & Cancer

New pathways to target breast cancer

A pathway helping the breast cancer protein BRCA1 repair damaged DNA has been identified by University of Queensland researchers in a study that will inform future targeted therapies.

Medical research

Changes detected in BRCA1 breast cells before they turn cancerous

A new study funded by Cancer Research UK has mapped out some of the earliest changes that occur in seemingly healthy breast tissue long before any tumors appear, which could have significant implications for the early detection ...

Oncology & Cancer

New mechanism of action for PARP inhibitors discovered

New understanding of how drugs called PARP inhibitors, which have already shown promise for the treatment of women with familial breast and ovarian cancers linked to BRCA mutations, exert their anticancer effects has led ...

Oncology & Cancer

Early menopause may occur in women with BRCA gene, study finds

Women with harmful mutations in the BRCA gene, which put them at higher risk of developing breast and ovarian cancer, tend to undergo menopause significantly sooner than other women, allowing them an even briefer reproductive ...

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