Oncology & Cancer

Searching for the 'signature' causes of BRCAness in breast cancer

Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature (a pattern of base swaps—e.g., Ts for Gs, Cs for As—throughout a genome) known in cancer genomics as "Signature ...

Oncology & Cancer

Gene increases risk of breast cancer to one in three by age 70

Breast cancer risks for one of potentially the most important genes associated with breast cancer after the BRCA1/2 genes are today reported in the New England Journal of Medicine. Women with mutations in the PALB2 gene have ...

Oncology & Cancer

Rapid genetic testing can help women choose breast cancer treatment

Women with breast cancer who are offered rapid genetic testing for BRCA1 and BRCA2 mutations—and who are able to receive their genetic test results prior to selecting treatment—were more likely to choose to have a bilateral ...

Oncology & Cancer

New cancer genes identified, opening door to targeted treatments

In a discovery that could lead to more targeted and effective treatments for certain lung and prostate cancers, researchers at the University of Virginia School of Medicine have identified two new cancer-causing gene mutations ...

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