Move over, cell signaling. Scientists seeking to understand embryonic development need to make room for metabolism, according to a new study, led by Harvard Medical School developmental biologist Olivier Pourquié, that also ...
Mar 7, 2017
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36
Mount Sinai researchers have discovered that a rheumatoid arthritis drug can block a metabolic pathway that occurs in tumors with a common cancer-causing gene mutation, offering a new possible therapy for aggressive cancers ...
Mar 2, 2017
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3
Discovery of a dual role played by the enzyme phosphoglycerate kinase 1 (PGK1) may indicate a new therapeutic target for glioblastoma, an often fatal form of brain cancer, according to researchers at The University of Texas ...
Feb 23, 2017
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0
The metabolic state of tumor cells contributes to signals that control their proliferation. German biochemist and Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism. ...
Feb 20, 2017
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7
Less aggressive cancers are known to have an intact genome—the complete set of genes in a cell—while the genome of more aggressive cancers tends to have a great deal of abnormalities. Now, a new multi-year study of DNA ...
Feb 16, 2017
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Researchers from the Chinese Academy of Sciences have discovered that the metabolic enzyme phosphoglycerate mutase 1 (PGAM1) helps cancer cells repair their DNA and found that inhibiting PGAM1 sensitizes tumors to the cancer ...
Jan 25, 2017
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3
For decades, scientists have tried to halt cancer by blocking nutrients from reaching tumor cells, in essence starving tumor cells of the fuel needed to grow and proliferate. Such attempts often have disappointed because ...
Jan 24, 2017
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Cancer cells love glucose, the simple sugar the body uses for energy, so a high-fat, low-carb diet should starve them, right?
Jan 12, 2017
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41
The importance of glutamine was made clear as a colon cancer specific metabolism. It is known that glutamine metabolism is important for pancreatic cancer, but the importance of glutamine metabolism for colon cancer has been ...
Jan 10, 2017
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2
Researchers have discovered a metabolic signature critical for the functioning of "cancer stem cells" that initiate tumor formation. The team also showed how to interfere with this metabolic mechanism in ovarian cancer, inhibiting ...
Jan 3, 2017
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