Genetics

Engineered capsids for efficient gene delivery to the eye

A rational design approach created novel variants of adeno-associated viral (AAV) capsids. These have improved transduction properties in the mouse retina and cornea. as reported in the peer-reviewed journal Human Gene Therapy.

Genetics

Tracking adeno-associated virus capsid evolution

Researchers have used high-throughput screening of adeno-associated viral (AAV) vector capsid libraries to maximize the likelihood of obtaining AAV variants with desired properties. As a result of these experiments, they ...

Medical research

Researchers describe building blocks of HIV's protective shell

The genome of the HIV-1 virus is protected by a conical-shaped protein shell called a capsid, which performs many functions crucial to viral infection—shielding the virus from the immune system, attaching to cell's transport ...

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