A better understanding of the role secreted inflammatory cytokines play in the tumor microenvironment that results in the differentiation of effector T cells into exhausted T cells points to possible approaches to improve ...
Aug 3, 2018
0
0
St. Jude Children's Research Hospital immunologists have discovered how immune cells called T cells become "exhausted"—unable to do their jobs of attacking invaders such as cancer cells or viruses. The finding is important ...
Jun 27, 2017
0
374
Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.
Sep 10, 2015
0
15
An 'exhausted' army of immune cells may not be able to fight off infection, but if its soldiers fight too hard they risk damaging the very body they are meant to be protecting, suggests new research from the University of ...
Jun 29, 2015
0
1530
Sometimes even cells get tired. When the T cells of your immune system are forced to deal over time with cancer or a chronic infection such as HIV or hepatitis C, they can develop 'T cell exhaustion,' becoming less effective ...
Jun 3, 2015
0
18
When fighting chronic viral infections or cancers, a key division of the immune system, known as CD8 T cells, sometimes loses its ability to effectively fight foreign invaders. Overcoming so-called T cell exhaustion is crucial ...
Feb 12, 2015
2
59
Killer T cells are one of the body's main lines of defense against pathogens. Their job is to kill infected cells so that the viruses inside cannot replicate and spread. But often the force of their attack wanes during a ...
Jan 26, 2015
0
6
Leaky intestines may cripple bacteria-fighting immune cells in patients with a rare hereditary disease, according to a study by researchers in Lausanne, Switzerland. The study, published in The Journal of Experimental Medicine ...
Sep 15, 2014
0
0
There has been an increase in the number of non-smokers being diagnosed with non-small cell lung cancer, according to new findings.
Sep 4, 2012
0
0
Rather than stimulating immune cells to more effectively battle cancerous tumors, treatment with the protein interleukin-12 (IL-12) has the opposite effect, driving these intracellular fighters to exhaustion, a Mayo Clinic ...
May 9, 2012
0
0
