Medical research

How mechanical forces nudge tumors toward malignancy

All cancers are the result of cells that have gone haywire, multiplying out of control and expanding beyond their normal constraints. But not all tumors are the same: for reasons that remain poorly understood, some are more ...

Genetics

Genetic mutations may be linked to infertility, early menopause

A new study from Washington University School of Medicine in St. Louis identifies a specific gene's previously unknown role in fertility. When the gene is missing in fruit flies, roundworms, zebrafish and mice, the animals ...

Medications

Malaria drug chloroquine does not inhibit SARS-CoV-2

More than 600,000 people worldwide have fallen victim to the lung disease COVID-19 so far, which is caused by the SARS coronavirus-2 (SARS-CoV-2). In order to obtain an effective therapy for COVID-19 as quickly as possible, ...

Diseases, Conditions, Syndromes

Freeze-framing the shape-shifting SARS-CoV-2 spike protein

The rod-like spike proteins on the surface of SARS CoV-2 are the tip of the spear of the COVID-19 pandemic. The spikes bind to human cells via the ACE2 receptor and then dramatically change shape, jack-knifing to fuse the ...

Neuroscience

New drug reduces stroke damage in mice

Neuroscientists at the University of Pittsburgh Brain Institute have identified a novel drug that could protect the brain during and after a stroke.

Medical research

Bioelectric signals in breast cancer metastasis studied

Metastasis accounts for approximately 90 percent of mortality in breast cancer patients. During the last few decades, there has been significant progress in understanding genetic, molecular and signaling mechanisms underpinning ...

Medical research

'Off-road' mode enables mobile cells to move freely

Leukocytes instantly move out of your blood vessels to the site of inflammation after an injury. Similarly, cancer cells, which can originate in any tissue or organ, can also spread and reproduce far away from their place ...

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