Within cells, molecules known as transfer RNAs, or "tRNAs," play an important but unglamorous workhorse role in keeping the genetic translation process moving along from codes of DNA to functional proteins.
Aug 26, 2020
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Discussions of cancer often stress the genetic mutations that drive disease by altering the normal function of cellular proteins. KRAS, for example, normally acts as an on/off switch for cellular proliferation, but mutations ...
May 11, 2023
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Maturity-onset diabetes of the young (MODY) is a disease caused by single-gene mutations. The genes typically affected by MODY are important for the development and function of beta-cells, which are crucial for maintaining ...
Mar 2, 2022
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Scientists say they have used the gene editing tool CRISPR inside someone's body for the first time, a new frontier for efforts to operate on DNA, the chemical code of life, to treat diseases.
Mar 4, 2020
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Many cells in the inner lining of the uterus carry 'cancer-driving' mutations that frequently arise early in life, report scientists from the Wellcome Sanger Institute, the University of Cambridge and their collaborators. ...
Apr 22, 2020
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Several gene mutations have been linked to Parkinson's disease, but exactly how and where some of them cause their damage has been unclear. A new Yale study, published in the Journal of Cell Biology, shows that one of the ...
Aug 10, 2018
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Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. Rather, the location of DNA mutations is relevant. Using ...
Nov 29, 2018
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The targeted anti-cancer therapies cetuximab and panitumumab are mainstays of treatment for advanced colorectal cancer, the second leading cause of cancer-related deaths in the United States. However, many patients have tumors ...
Oct 17, 2017
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Evolutionary theory says mutations are blind and occur randomly. But in the phenomenon of adaptive mutation, cells can peek under the blindfold, increasing their mutation rate in response to stress.
Aug 25, 2015
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Mutations in a crucial gene are the key reason that chemotherapy fails in some patients with blood cancer, a study by Nanyang Technological University, Singapore (NTU Singapore) and Singapore General Hospital (SGH) has found.
Dec 6, 2021
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