Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each ...
Oct 27, 2011
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Scientists have found that key metabolites in blood – chemical 'fingerprints' left behind as a result of early molecular changes before birth or in infancy – could provide clues to a person's long-term overall health ...
Jul 8, 2013
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(Medical Xpress)—The rhythm of life is driven by the cycles of day and night, and most organisms carry in their cells a common, (roughly) 24-hour beat. In animals, this rhythm emerges from a tiny brain structure called ...
Aug 28, 2012
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Growing evidence suggests that there may be a link between diabetes and Alzheimer's disease, but the physiological mechanisms by which diabetes impacts brain function and cognition are not fully understood. In a new study ...
Oct 26, 2012
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The study, led by Professor Per Uhlén, presents a model and mechanism for how the risk gene CACNA1C can affect brain function and the risk of psychiatric illness.
Feb 15, 2022
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A cellular protein called HDAC6, newly characterized as a gatekeeper of steroid biology in the brain, may provide a novel target for treating and preventing stress-linked disorders, such as depression and post-traumatic stress ...
Apr 23, 2012
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Poor diet and lifestyle choices set the stage for obesity and diabetes, but the immune system plays a relatively underappreciated role in accelerating this process. Metabolic changes in fat cells stimulate the release of ...
Mar 15, 2013
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(Medical Xpress)—Controlling the symptoms of schizophrenia is the job of antipsychotic drugs which block a set of specific neural signals. But the way these drugs work can lead to a host of severe and debilitating long-term ...
Apr 5, 2013
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Several substances inhibiting so-called HDAC enzymes have been studied in trials searching for new anti-cancer drugs in recent years. "Trials have shown that HDAC inhibitors are very effective in arresting growth of cultured ...
Nov 5, 2012
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Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor ...
Apr 18, 2013
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