Loss of TLK1 and TLK2 results in extensive DNA damage during DNA replication and in cancer cell death. Depletion of TLK1/2 enhances the effectiveness of some chemotherapeutic agents currently being tested in clinical trials
Aug 9, 2018
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Bioengineers at the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have developed a smart anti-cancer nanoparticle with precisely targeted tumor-killing activity superior to previous technologies.
Apr 5, 2018
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The development of chemotherapeutic drugs to treat various cancers has been fraught with challenges. One of the toughest is the acute and long-term toxicity of drugs and its severe side-effects on almost all organs in the ...
Mar 29, 2018
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(HealthDay)—Curcumin can resensitize chemoresistant pancreatic ductal adenocarcinoma (PDAC) cells through inhibition of the polycomb repressive complex 2 (PRC2)-PVT1-c-Myc axis, according to a study published online July ...
Aug 2, 2017
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A potent chemotherapy drug can be life saving for children with cancer, but a new review highlights how it can have long-lasting negative effects on the heart. The review, which is published in the British Journal of Clinical ...
Sep 5, 2016
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A surprising result in an experiment on Salmonella bacteria has led to a discovery that may make drug-resistant cancer cells more treatable by conventional chemotherapies. Scientists at UMass Medical School have found that ...
Jul 25, 2016
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Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer in Switzerland. Despite intensive chemotherapy, one fifth of the patients suffer a relapse, which usually goes hand in hand with a poor prognosis. ...
May 18, 2016
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Standard treatment for prostate cancer can include chemotherapy that targets receptors on cancer cells. However, drug-resistant cancer cells can emerge during chemotherapy, limiting its effectiveness as a cancer-fighting ...
Apr 14, 2016
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Researchers from the University of Southampton have established that eggs have a protective 'checkpoint' that helps to prevent DNA damaged eggs being fertilised.
Nov 2, 2015
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A study conducted by the Spanish National Cancer Research Centre´s (CNIO) Genomic Instability Group, led by Óscar Fernández-Capetillo, describes for the first time in mammals, the role played by the SMC5/6 protein complex ...
Oct 7, 2015
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