Lamivudine, a commonly-used antiretroviral drug for treating HIV, improves cognition in a mouse model of Down syndrome, according to the findings of a joint new study by researchers at the Centre for Genomic Regulation (CRG) ...
Jun 28, 2022
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Researchers have been chipping away at the genetic causes of congenital heart disease (CHD) for a couple of decades. About 45% of cases of CHD have an identifiable cause, including chromosomal abnormalities, genetic variants ...
Apr 8, 2024
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Serious conditions, including sepsis, stem from inflammation in the body, and there is a lack of effective medication for sepsis. A chromosomal protein called high-mobility group box 1 (HMGB1), secreted by immune and dying ...
Jul 2, 2019
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Cohesin is a protein complex that is essential for chromosome segregation in dividing cells. Recent evidence suggests that it also plays an important role in 3-D genome architecture, which folds like origami and regulates ...
Jun 18, 2019
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Break apart a couple worm-like chromosomes and they may reconnect with mismatched tips and tails – such is the case of the EML4-ALK fusion gene that creates 2-7 percent of lung cancers. Almost exactly a year ago, the FDA ...
Aug 28, 2012
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Scientists at Cold Spring Harbor Laboratory (CSHL) and Memorial Sloan-Kettering Cancer Center have amassed strong experimental evidence implying that commonly occurring large chromosomal deletions that are seen in many cancer ...
May 7, 2012
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The European X-ALD project undertook an initiative to understand the mechanisms responsible for the pathogenesis of adrenoleukodystrophy (ALD). The gene therapy approach for treating ALD developed during the study brings ...
Jul 30, 2012
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(HealthDay)—Iclusig (ponatinib) has been approved by the U.S. Food and Drug Administration to treat two rare forms of leukemia..
Dec 16, 2012
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The discovery of an unexpected function for a gene that was associated to another process in the organism might be a solution in search of a problem, a clue to unsuspected connections. That is what has happened with RAP1, ...
Jun 20, 2013
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(Medical Xpress)—Six years ago, Boise State University biology professor Greg Hampikian and computer science colleague Tim Andersen announced that they had identified tiny DNA and protein sequences that were absent in nature. ...
Oct 9, 2012
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