Neuroscience

Researchers identify protein involved in cocaine addiction

Mount Sinai researchers have identified a protein produced by the immune system—granulocyte-colony stimulating factor (G-CSF)—that could be responsible for the development of cocaine addiction.

Neuroscience

Abnormal brain structure linked to chronic cocaine abuse

Researchers at the University of Cambridge have identified abnormal brain structures in the frontal lobe of cocaine users' brains which are linked to their compulsive cocaine-using behaviour. Their findings were published ...

Neuroscience

Faulty signaling in brain increases craving for sugar and drugs

When glutamate and dopamine do not collaborate as they should in the brain's signal system, the kick that alcohol, sugar, or other drugs induce increases. This is shown in a new Swedish-Canadian study on mice being published ...

Neuroscience

How the brain puts the brakes on the negative impact of cocaine

Research published by Cell Press in the January 12 issue of the journal Neuron provides fascinating insight into a newly discovered brain mechanism that limits the rewarding impact of cocaine. The study describes protective ...

Medical research

Possible tool to help cocaine users kick the habit

Medicines which increase levels of the brain chemical dopamine may hold the key to helping those addicted to cocaine and amphetamines kick the habit, researchers from the University of Cambridge have found.

Psychology & Psychiatry

Addiction: Can you ever really completely leave it behind?

It is often said that once people develop an addiction, they can never completely eliminate their attraction to the abused substance. New findings provide further support for this notion by suggesting that even long-term ...

Psychology & Psychiatry

Nucleus accumbens recruited by cocaine, sugar are different

Nucleus accumbens in the brain play a central role in the risk-reward circuit. Their operation is based chiefly on three essential neurotransmitters: dopamine, which promotes desire; serotonin, whose effects include satiety ...

Neuroscience

Mechanism links substance abuse with vulnerability to depression

It is well established that a mood disorder can increase an individual's risk for substance abuse, but there is also evidence that the converse is true; substance abuse can increase a person's vulnerability to stress-related ...

Neuroscience

Chronic cocaine use triggers changes in brain's neuron structure

Chronic exposure to cocaine reduces the expression of a protein known to regulate brain plasticity, according to new, in vivo research on the molecular basis of cocaine addiction. That reduction drives structural changes ...

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