Addiction

Blocking dopamine weakens effects of cocaine

Blocking dopamine receptors in different regions of the amygdala reduces drug seeking and taking behavior with varying longevity, according to research in rats published in eNeuro.

Addiction

Record cocaine seized in Europe as challenges grow: EU report

European authorities are seizing record quantities of increasingly pure cocaine, the EU's drugs agency said in a report published Thursday, pointing also to a growing use of synthetic drugs and dealing via smartphones.

Medical research

Preventing relapse in recovery from cocaine use disorder

A study conducted at the University of São Paulo (USP) in Brazil and described in an article published in the journal Drug and Alcohol Dependence may help healthcare workers identify patients who risk relapse after undergoing ...

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Cocaine

Cocaine (benzoylmethylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.

Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.

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