Medications

Feds to let states tap opioid funds for meth, cocaine surge

Alarmed by a deadly new twist in the nation's drug addiction crisis, the government will allow states to use federal money earmarked for the opioid epidemic to help growing numbers of people struggling with meth and cocaine.

Addiction

Study examines opioid involvement in US drug overdoses

Fatal overdoses involving stimulants (cocaine and other psychostimulants, primarily methamphetamine) have been increasing over the past few years. A recent analysis published in Addiction found that in 2016, 27% of overdose ...

Addiction

Blocking dopamine weakens effects of cocaine

Blocking dopamine receptors in different regions of the amygdala reduces drug seeking and taking behavior with varying longevity, according to research in rats published in eNeuro.

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Cocaine

Cocaine (benzoylmethylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.

Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.

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