Addiction

Record cocaine seized in Europe as challenges grow: EU report

European authorities are seizing record quantities of increasingly pure cocaine, the EU's drugs agency said in a report published Thursday, pointing also to a growing use of synthetic drugs and dealing via smartphones.

Medical research

Preventing relapse in recovery from cocaine use disorder

A study conducted at the University of São Paulo (USP) in Brazil and described in an article published in the journal Drug and Alcohol Dependence may help healthcare workers identify patients who risk relapse after undergoing ...

Neuroscience

Brain research reveals a circuit for cocaine relapse

Approximately 1.5 million Americans use cocaine in a given year, according to the National Institute on Drug Abuse. Many are repeat users. Unfortunately, there are currently no FDA-approved medicinal treatments for cocaine ...

Psychology & Psychiatry

Menstrual cycle phase influences cocaine craving

Menstrual cycle may influence addiction risk in women, according to a new study in Biological Psychiatry by researchers at the National Institute on Drug Abuse and University of Maryland School of Medicine. In female rats, ...

Psychology & Psychiatry

Women's hormones play role in drug addiction, higher relapse rates

Women's hormonal cycles may not only make them more prone to drug addiction but also more affected by triggers that lead to relapse, a new Vanderbilt University study revealed. The findings are especially significant since ...

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Cocaine

Cocaine (benzoylmethylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.

Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.

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