Addiction

Predisposition to addiction may be genetic

People who have a high sensation-seeking personality trait may be more likely to develop an addiction to cocaine, according to a Rutgers study.

Neuroscience

A brain signature that predicts vulnerability to addiction

A team of neurobiologists at the Institut de Neurosciences de la Timone (CNRS/Aix-Marseille Université) has just shown that within a population of rats it can predict which will become cocaine addicts.

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Cocaine

Cocaine (benzoylmethylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor, a norepinephrine reuptake inhibitor and a serotonin reuptake inhibitor, which mediates functionality of such as an exogenous DAT ligand. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive.

Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.

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