Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to ...
Aug 21, 2019
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Over the past two decades, numerous complex cancer therapies called antibody drug conjugates (ADCs) have been tested in clinical trials and approved for use in patients. Investigators recently performed a comprehensive analysis ...
Nov 21, 2022
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An international team led by the University of Bonn (Germany) identified and further developed novel antibody fragments against the SARS coronavirus-2. These "nanobodies" are smaller than classic antibodies penetrating the ...
Jan 12, 2021
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Environment moulds behaviour - and not just that of people in society, but also at the microscopic level. This is because, for their function, neurons are dependent on the cell environment, the so-termed extracellular matrix. ...
May 6, 2013
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Researchers have gained new understandings of two key complexes of cancer-related proteins by producing the most detailed ever maps of the structures they form when they come together.
Jan 6, 2020
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Researchers from Tokyo Medical and Dental University (TMDU) use mouse embryonic stem cells to engineer three-dimensional functional heart organoids resembling the developing heart
Sep 16, 2020
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Researchers at the University of Oxford have now uncovered a new target for sleep investigations within the mammalian brain—the cerebral cortex. The paper was published today in Nature Neuroscience.
Aug 3, 2021
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Deep inside our brain is a region called the hippocampus. It plays a crucial role in learning and memory, and its progressive deterioration with age is functionally linked to a variety of human neurodegenerative diseases. ...
Jul 29, 2021
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Scientists at St. Jude Children's Research Hospital have revealed the complex structure of two Parkinson's disease-related proteins, both of which are implicated in late-onset cases. Leucine-rich repeat kinase 2 (LRRK2) is ...
Dec 21, 2023
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Primates are among the most intelligent creatures with distinct cognitive abilities. Their brains are relatively large in relation to their body stature and have a complex structure. However, how the brain has developed over ...
May 16, 2023
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