How a risk gene for schizophrenia affects the brain
Scientists have for the first time shown how the disruption of a key gene involved in mental illness impacts on the brain.
May 25, 2015
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Scientists have for the first time shown how the disruption of a key gene involved in mental illness impacts on the brain.
May 25, 2015
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Mice engineered with a human gene for schizophrenia and exposed to lead during early life exhibited behaviors and structural changes in their brains consistent with schizophrenia. Scientists at Columbia University's Mailman ...
May 31, 2013
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(Medical Xpress) -- Johns Hopkins researchers say they have discovered a cause-and-effect relationship between two well-established biological risk factors for schizophrenia previously believed to be independent of one another.
Jul 17, 2012
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(Medical Xpress) -- Scientists at the University of Glasgow have identified a potential target for the treatment of schizophrenia.
May 11, 2011
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In a new study, scientists from Forschungszentrum Jülich and Heinrich Heine University Düsseldorf (HHU) have demonstrated for the first time that improper protein conformation is linked to the development of certain psychiatric ...
Jan 11, 2022
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In a study of adolescent mice with a version of a gene linked to serious human mental illnesses, Johns Hopkins Medicine researchers say they have uncovered a possible explanation for how marijuana may damage the brains of ...
Dec 17, 2018
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There may be a genetic connection between some mental health disorders and type 2 diabetes. In a new report appearing in the February 2016 issue of The FASEB Journal, scientists show that a gene called "DISC1," which is believed ...
Feb 5, 2016
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It has long been known that psychiatric disorders, such as schizophrenia, have been associated with a higher risk of type 2 diabetes. In a new study published online in The FASEB Journal, a UMass Medical School research team, ...
Nov 20, 2015
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(Medical Xpress) -- Carrying single DNA letter changes from two different genes together may increase the risk of developing schizophrenia, Johns Hopkins researchers reported in the November 16 issue of Neuron.
Dec 16, 2011
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Faulty wiring of the prefrontal cortex during development leads to abnormal brain activity and cognitive impairments related to mental illness, according to a mouse study published in JNeurosci.
Jan 7, 2019
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Disrupted in schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research.
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