Type 2 diabetes alters the behavior of disks in the vertebral column, making them stiffer, and also causes the disks to change shape earlier than normal. As a result, the disk's ability to withstand pressure is compromised. ...
Feb 13, 2024
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Consistent daily patterns of exercise and rest can synchronize the local body clocks associated with joints and spine with the brain clock, potentially helping individuals to maintain skeletal health, improve athletic performance ...
Nov 14, 2023
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The leading cause of vision loss in Western countries is age-related macular degeneration (AMD), a deterioration of central vision that begins when droplets of lipids and proteins called lipofuscin accumulate in the retina ...
May 11, 2023
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A recent study from University Hospitals (UH) Connor Whole Health has found that adults who initially visit a chiropractor to receive spinal manipulation for low back pain caused by disc herniation or radiculopathy (i.e., ...
Dec 19, 2022
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While Blu-ray discs may not have found success supplanting DVDs in the home entertainment field, Blu-ray technology is an engineering feat enabling advances in medical imaging technologies at UConn.
May 25, 2022
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Chronic back pain affects upwards of 15 million adults in the US, racking up billions in healthcare costs and lost work days. Degeneration of the discs that cushion and support vertebrae, a common occurrence of aging, is ...
Sep 3, 2021
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A new two-step technique to repair herniated discs uses hyaluronic acid gel to re-inflate the disc and collagen gel to seal the hole, essentially repairing ruptured discs like you'd repair a flat tire.
Mar 11, 2020
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Researchers may have found a way to press pause on spinal disc injuries, giving doctors more time to treat them before worse issues develop. The Penn Medicine-led team discovered that cells in the outer region of spinal discs ...
Oct 14, 2019
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For the first time, bioengineered spinal discs were successfully implanted and provided long-term function in the largest animal model ever evaluated for tissue-engineered disc replacement. A new Penn Medicine study published ...
Nov 21, 2018
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Neck and back pain are debilitating and expensive: an estimated 80 percent of adults will suffer one or both at some point during their lives, racking up $86 billion in medical costs and missed work in the United States alone. ...
Apr 17, 2018
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PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (disks large homolog 4) gene.
PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
PSD-95 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.
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