A new study suggests a dual mechanism of actions of overactive and cytosolic re-localized BRCA1, the major guardian of genomic stability, in neurons death by aberrant DNA damage response and presenilin 1 dysfunction in Alzheimer's ...
Feb 7, 2018
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Cancer is essentially a disease of the cell replication cycle. The goal of treating the disease is to permanently kill off the cells that replicate with abandon without any molecular brakes. Chemotherapy and radiation cause ...
Jul 31, 2017
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Dr Ross Carruthers has recently been awarded a CRUK Clinican Scientist Fellowship. A consultant radiation oncologist, now based at the University of Glasgow, he plans to investigate DNA damage response mechanisms in glioblastoma, ...
Jun 21, 2017
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Immune diseases like multiple sclerosis and hemophagocytic lymphohistiocytosis unleash destructive waves of inflammation on the body, causing death or a lifetime of illness and physical impairment. With safe and effective ...
May 22, 2017
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Scientists at The Wistar Institute have unveiled part of the protein complex that protects telomeres—the ends of our chromosomes. The study, published online in Nature Communications, explains how a group of genetic mutations ...
Apr 11, 2017
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Progressively shortening telomeres—the protective caps on the end of chromosomes—may be responsible for the weakened, enlarged hearts that kill many sufferers of Duchenne muscular dystrophy, according to a study by researchers ...
Oct 31, 2016
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Researchers studying reproductive science identified a network of proteins often linked to cancer as also important to male fertility and the birth of healthy offspring, according to a study in the Oct. 18 online issue of ...
Oct 18, 2016
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A recent study found that that sperm of men who smoke has a greater extent of DNA damage than that of non-smokers.
Jun 22, 2016
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A group of researchers at Osaka University found that if DNA damage response (DDR) does not work when DNA is damaged by radiation, proteins which should be removed remain instead, and a loss of genetic information can be ...
May 24, 2016
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Female cancer patients of reproductive age could preserve their fertility during radiation and chemotherapy through treatments that target the DNA damage response in oocytes (the cells that develop into eggs), an approach ...
May 17, 2016
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