Researchers from the Novo Nordisk Foundation Center for Protein Research at the Faculty of Health and Medical Sciences have characterised a new protein that is important to the genetic stability of cells. It may be significant ...
May 4, 2018
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A new research paper titled "Roles of USP1 in Ewing sarcoma" has been published in Genes & Cancer.
Feb 14, 2024
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Double-stranded breaks in cellular DNA can trigger tumorigenesis. Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich, Germany, have determined the structure of a protein involved in the repair and signaling ...
Jun 19, 2012
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New research provides critical insights into how normal breast precursor cells may be genetically vulnerable to develop into cancer. The research is published June 4th in the inaugural issue of Stem Cell Reports, an open-access ...
Jun 4, 2013
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Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers—ATR inhibitor elimusertib and PARP inhibitor AZD5305—are safe and clinically beneficial in treating ...
Apr 11, 2022
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Dr Ross Carruthers has recently been awarded a CRUK Clinican Scientist Fellowship. A consultant radiation oncologist, now based at the University of Glasgow, he plans to investigate DNA damage response mechanisms in glioblastoma, ...
Jun 21, 2017
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A new research paper titled "ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines" has been published in Oncotarget.
Jan 17, 2024
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A new study suggests a dual mechanism of actions of overactive and cytosolic re-localized BRCA1, the major guardian of genomic stability, in neurons death by aberrant DNA damage response and presenilin 1 dysfunction in Alzheimer's ...
Feb 7, 2018
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Protein NBS1, which plays a key role in DNA damage repair, is required for macrophage functional activity. This is one of the conclusions of a scientific paper published in the journal Blood by a team of experts from the ...
Sep 14, 2015
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IRCM researchers led by Javier M. Di Noia, PhD, uncovered a new function of AID, a crucial enzyme for the immune response. The discovery, recently published by the scientific journal Proceedings of the National Academy of ...
Mar 27, 2014
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