Immunology
How our immune system detects broken DNA
Our immune system is working every day to protect us from bacteria, viruses, and parasites, but it can also detect when our own cells are damaged.
Sep 6, 2018
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Page 2 - News tagged with dna damage response
Medical research
How DNA damage turns immune cells against cancer
Cancer is essentially a disease of the cell replication cycle. The goal of treating the disease is to permanently kill off the cells that replicate with abandon without any molecular brakes. Chemotherapy and radiation cause ...
Jul 31, 2017
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Immunology
Experimental therapy for immune diseases hits Achilles heel of activated T cells
Immune diseases like multiple sclerosis and hemophagocytic lymphohistiocytosis unleash destructive waves of inflammation on the body, causing death or a lifetime of illness and physical impairment. With safe and effective ...
May 22, 2017
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Genetics
How two telomere proteins interact with each other and the functional effects of cancer-associated mutations
Scientists at The Wistar Institute have unveiled part of the protein complex that protects telomeres—the ends of our chromosomes. The study, published online in Nature Communications, explains how a group of genetic mutations ...
Apr 11, 2017
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Medical research
DNA damage response links short telomeres, heart disorder in Duchenne muscular dystrophy
Progressively shortening telomeres—the protective caps on the end of chromosomes—may be responsible for the weakened, enlarged hearts that kill many sufferers of Duchenne muscular dystrophy, according to a study by researchers ...
Oct 31, 2016
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Genetics
Protein network linked to cancer is critical to male fertility
Researchers studying reproductive science identified a network of proteins often linked to cancer as also important to male fertility and the birth of healthy offspring, according to a study in the Oct. 18 online issue of ...
Oct 18, 2016
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Oncology & Cancer
Chemistry nobel DNA research lays foundation for new ways to fight cancer
Our cells are up against a daily onslaught of damage to the DNA that encodes our genes. It takes constant effort to keep up with the DNA disrepair – and if our cells didn't bother to try to fix it, we might not survive. ...
Oct 9, 2015
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Genetics
Research finds key to gene stability, possible new cancer targets
Researchers in the UC Department of Cancer Biology have found new protein players that help keep genome stability—a promising finding with the potential to help with the development of new targeted therapeutics in diseases ...
Mar 10, 2015
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Oncology & Cancer
Protein ZEB1 promotes breast tumor resistance to radiation therapy
Twist, Snail, Slug. They may sound like words in a children's nursery rhyme, but they are actually the exotic names given to proteins that can generate cells with stem cell-like properties that have the ability to form diverse ...
Aug 4, 2014
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Oncology & Cancer
Critical pathway in cell cycle may lead to cancer development
A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. Their findings on telomeres, the stretches ...
Jul 11, 2013
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