News tagged with dna methylation

Related topics: genes · cancer · dna sequences · gene expression · embryonic stem cells

Risk of obesity influenced by changes in our genes

These changes, known as epigenetic modifications, control the activity of our genes without changing the actual DNA sequence. One of the main epigenetic modifications is DNA methylation, which plays a key role in embryonic ...

3 hours ago
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After the epigenome: The epitranscriptome

Our genome is made up of 6,000 million pieces of DNA that combine four "flavors": A, C, G and T (Adenine, Cytosine, Guanine and Thymine). It is our Alphabet. But to this base we must add some regulation, just like the spelling ...

Mar 22, 2017
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DNA labels predict mortality

Various chemical modifications in the genome determine whether genes are read or deactivated. Methyl labels in the DNA play a key role in this "epigenetic" regulation of gene activity. Life style and environmental factors ...

Mar 20, 2017
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Obesity reprogrammes muscle stem cells

Obesity is associated with reduced muscle mass and impaired metabolism. Epigenetic changes that affect the formation of new muscle cells may be a contributing factor, according to new research from Lund University, Sweden.

Feb 22, 2017
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DNA methylation

DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the best characterized epigenetic mechanism. Because methylation is a common capability of all viruses for self non-self identification, the epigenetic code could be a persistent remnant of ancient viral infection events.

DNA methylation involves the addition of a methyl group to DNA — for example, to the number 5 carbon of the cytosine pyrimidine ring — in this case with the specific effect of reducing gene expression. DNA methylation at the 5 position of cytosine has been found in every vertebrate examined. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.

In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide but guanine.

Research has suggested that long term memory storage in humans may be regulated by DNA methylation.

This text uses material from Wikipedia, licensed under CC BY-SA

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