News tagged with dna methylation

Related topics: genes · cancer · dna sequences · gene expression · embryonic stem cells

Immune cells turn back time to achieve memory

Memory T cells earn their name by embodying the memory of the immune system - they help the body remember what infections or vaccines someone has been exposed to. But to become memory T cells, the cells go backwards in time, ...

Dec 13, 2017
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Tracking down genetic influences on brain disorders

New findings will help to identify the genetic causes of brain disorders: researchers at the Universities of Basel, Bonn and Cologne have presented a systematic catalog of specific variable locations in the genome that influence ...

Nov 27, 2017
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Mysterious DNA modification seen in stress response

With advances in genomics, scientists are discovering additional components of the DNA alphabet in animals. Do these unusual chemical modifications of DNA have a special meaning, or are they just signs that cellular machines ...

Oct 24, 2017
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DNA methylation

DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the best characterized epigenetic mechanism. Because methylation is a common capability of all viruses for self non-self identification, the epigenetic code could be a persistent remnant of ancient viral infection events.

DNA methylation involves the addition of a methyl group to DNA — for example, to the number 5 carbon of the cytosine pyrimidine ring — in this case with the specific effect of reducing gene expression. DNA methylation at the 5 position of cytosine has been found in every vertebrate examined. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.

In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide but guanine.

Research has suggested that long term memory storage in humans may be regulated by DNA methylation.

This text uses material from Wikipedia, licensed under CC BY-SA

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