A study that examined 17 million mutations in the genomes of 650 cancer patients concludes that large differences in mutation rates across the human genome are caused by the DNA repair machinery.
Feb 23, 2015
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Fanconi anemia (FA) is a genetic disease affecting small children characterized by bone-marrow failure, developmental abnormalities and predisposition to multiple forms of cancer. The molecular mechanisms behind FA are inherited ...
Oct 14, 2020
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When cells suffer too much DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, cancer cells often ignore these signals, flourishing even after chemotherapy drugs have ravaged their ...
May 14, 2013
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Like jewels in a vault, our precious genetic material is stored in the nucleus of a cell—sequestered away from potentially damaging cellular components and toxins so that no harm can come to it. Yet over the course of a ...
Apr 12, 2016
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Over the last several years, research teams across the world have scoured the genomes of cancer cells in a quest to uncover the genes that drive tumor growth. Meticulous analyses of the many thousands of genetic mutations ...
May 6, 2016
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Alveolar rhabdomyosarcoma is a type of rare pediatric tumor. For more than 40 years there have not been any new developments regarding treatment. Research led by Prof. Dr. Anton Henssen at Charité University Berlin has now ...
Sep 19, 2022
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A Florida State University College of Medicine researcher has made a discovery that alters our understanding of how the body's DNA repair process works and may lead to new chemotherapy treatments for cancer and other disorders.
Mar 8, 2022
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Studying two rare inherited cancer syndromes, Yale Cancer Center (YCC) scientists have found the cancers are driven by a breakdown in how cells repair their DNA. The discovery, published today in Nature Genetics, suggests ...
Jul 16, 2018
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St. Michael's Hospital and King Saud University have received their first joint U.S. patent to use the BRCA1 gene as a therapy for cardiovascular disease.
Feb 10, 2012
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A global collaboration of scientists has more than doubled the known number of regions on the human genome that influence the risk of developing melanoma.
Apr 27, 2020
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