PARP inhibitors are rapidly transforming the treatment of ovarian, breast, prostate and other types of cancer. To develop these drugs, researchers supported by Cancer Research UK had to decipher how blocking DNA repair could ...
Sep 25, 2020
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Women who are at risk for breast cancer may also be at greater risk for heart disease, new research has found.
Dec 20, 2011
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The nuclear envelope (NE) is composed of the outer nuclear membrane (ONM) and the inner nuclear membrane (INM), which are separated by the perinuclear space and joined at nuclear pore complexes. INM proteins play crucial ...
Dec 8, 2021
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Researchers at Karolinska Institutet and universities in Hong Kong have found a new molecular mechanism for DNA repair involving an unexpected interaction between the PARP-1 protein and sleep proteins in humans. Their discovery ...
Oct 2, 2015
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In a newly reported set of experiments that show the value of a particularly precise but difficult genetic engineering technique, researchers at Brown University and the University of California–Irvine have created a Drosophila ...
Oct 11, 2012
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Researchers at the University of Michigan's C.S. Mott Children's Hospital have identified a promising new target for developing new therapies for kids with high-risk neuroblastoma, according to a new study published in Molecular ...
Jan 21, 2015
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Using technology they developed, UT Southwestern Medical Center researchers have identified a previously unknown role of a certain class of proteins: as regulators of gene activity and RNA processing.
Aug 15, 2016
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Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive ...
Sep 17, 2012
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A new study by Claudia Kutter's research group at the Department of Microbiology, Tumor and Cell Biology (MTC) has identified potential pitfalls in the use of the gene editing technique CRISPR-Cas9, a gene scissors that is ...
Nov 21, 2023
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Researchers have identified a protein critical for the survival of a particular type of tumor cell, according to a study published today in eLife.
Mar 26, 2019
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