Enzymes inside cells that normally repair damaged DNA sometimes wreck it instead, researchers at the Stanford University School of Medicine have found. The insight could lead to a better understanding of the causes of some ...
Nov 26, 2014
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Ewing's sarcoma is a bone cancer commonly diagnosed in about 250 U.S. teenagers per year. If early chemotherapy is effective, improvement can be durable. But for children and teens who respond poorly to a first attempt at ...
Jun 30, 2012
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(Medical Xpress)—A molecule originally implicated in DNA repair may also be a crucial factor in preventing tumours such as medulloblastoma, a type of childhood brain tumour, according to research published today in Science.
Oct 11, 2013
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Scientists at St. Jude Children's Research Hospital have identified the structure of double-strand DNA break repair by PARP enzymes. The findings show that PARP2 can bridge the gap, bringing two broken DNA ends together.
Sep 16, 2020
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Leprosy is an infectious disease with gruesome symptoms. It damages the skin, peripheral nerves, the upper respiratory tract, and the eyes. Despite being curable with multidrug therapy, leprosy still persists in many developing ...
Jan 24, 2018
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A DNA repair pathway-focused score has the potential to help determine if first-line platinum based chemotherapy can benefit advanced-stage ovarian cancer patients, according to a study published April 13 in the Journal of ...
Apr 13, 2012
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Targeting a specific cancer survival gene in colorectal cancer could lead to new treatment options for advanced disease, new research suggests.
Apr 12, 2021
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The ongoing fight of science against cancer has made great strides, but cancer cells have not made it easy. The complexity of cancer cells and their adaptive evolutionary nature complicate the search for effective cures. ...
Feb 16, 2021
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St. Jude Children's Research Hospital scientists studying two rare, inherited childhood neurodegenerative disorders have identified a new, possibly common source of DNA damage that may play a role in other neurodegenerative ...
May 9, 2014
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Walter and Eliza Hall Institute researchers have uncovered a key factor protecting against age-related DNA damage, providing important clues about how our body guards against cancer.
Oct 4, 2018
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