Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant ...
Dec 9, 2012
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The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch anything ...
Mar 12, 2012
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BOSTON--Researchers at Dana-Farber Cancer Institute have demonstrated a molecular strategy they say could make a much larger variety of tumors treatable with PARP inhibitors, a promising new class of cancer drugs.
Jun 29, 2011
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Ground breaking research could reduce the recurrence of prostate cancer in males, a new study in the journal Nature Communications reports.
Sep 5, 2017
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(Medical Xpress)—A team of researchers led by the Institute of Cancer Research, London, have found that rare mutations in a gene called PPM1D are linked to an increased risk of breast and ovarian cancer. The mutations are ...
Dec 17, 2012
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Researchers at The Wistar Institute have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers ...
Dec 19, 2017
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A new statistical tool developed by researchers at the University of Chicago improves the ability to find genetic variants that cause disease. The tool, described in a new paper published January 26, 2024, in Nature Genetics, ...
Jan 26, 2024
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A study led by The University of Texas MD Anderson Cancer Center furthered understanding about mitochondria, the cell components known as the "powerhouse of the cell." Knowing more about the genome is crucial given that mitochondria ...
Feb 6, 2020
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A team of researchers at the University of Cambridge has identified a protein complex that might explain why some cancer patients treated with the revolutionary new anti-cancer drugs known as PARP inhibitors develop resistance ...
Jul 24, 2018
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A global collaboration involving the Sunshine Coast Health Institute (SCHI) and the University of the Sunshine Coast (UniSC) has made a breakthrough discovery that could fast track diagnosis and support for families affected ...
Aug 19, 2022
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