Scientists have revealed details of the discovery of new inhibitors of the BCL6 protein, which is involved in driving several cancer types including the blood cancer B-cell lymphoma.
Feb 9, 2023
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A new library documenting hundreds of mutations can help to explain why some cancers don't respond to immunotherapies, and highlights potential pathways that could be drug targets in the future.
Jan 20, 2023
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Because glioblastoma, a highly aggressive and lethal brain cancer, is resistant to conventional therapies, investigators are searching for characteristics of glioblastoma cells that could point to promising drug targets.
Jan 19, 2023
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All living organisms on Earth are exposed to a 24-hour day-night cycle. This cycle is the reason why people rest during the darkness of night and are active during the light of day. Consequently, all human body functions ...
Dec 13, 2022
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The pharmaceutical company Roche has announced that two phase III trials of the potential Alzheimer's drug gantenerumab did not achieve the goal of slowing clinical decline in participants with early Alzheimer's disease.
Nov 15, 2022
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Researchers report that a drug targeting the cancer-causing gene MYC inhibits the function of the gene in a phase I clinical trial. Until now, no other drug has been able to do this safely and effectively.
Oct 26, 2022
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A cautionary tale has developed a new twist this year, as an alarming opioid has become the latest drug feared to be lurking inside trick-or-treat hauls for Halloween.
Oct 26, 2022
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Scientists at deCODE genetics, a subsidiary of Amgen, published today a large genome-wide association study on nonalcoholic fatty liver disease (NAFLD) in Nature Genetics. Sequence variants that associate with NAFLD were ...
Oct 24, 2022
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The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of ...
Sep 13, 2022
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Cells have an efficient waste disposal system. Proxidrugs utilize this system as part of new treatments for cancer, infections and Alzheimer's disease. Scientists at the Fraunhofer Institute for Translational Medicine and ...
Sep 1, 2022
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