Medical research

Predicting toxicity in the drug development pipeline

University College Dublin researchers have reported in Molecular & Cellular Proteomics on a proof-of-principle study that may benefit the pharmaceutical industry in the future by providing a roadmap for large scale pre-clinical ...

Diseases, Conditions, Syndromes

New safety data for the most commonly used drug to treat Chagas disease

The frequency of adverse reactions to benznidazole is high when treating chronic Chagas patients, although the effects were mostly mild, according to a study led by ISGlobal, in collaboration with the Hospital Clinic of Barcelona. ...

Medications

Curbs on legal highs cut need for hospital care

Fewer people sought hospital treatment for the toxic effects of so-called legal highs following temporary restrictions, a study based at an Edinburgh hospital suggests.

Oncology & Cancer

Step closer to predicting cancer patients' drug toxicity

Being able to predict that a patient will adversely react to a drug that's meant to be treating them is a key aim of personalised medicine, and could help to improve the patient's overall treatment.

Oncology & Cancer

Potential upgrades on in vitro toxicological cell-based models

Over the last 100 years, knowledge regarding drug toxicity has increased significantly, especially since the thalidomide tragedy of the mid-20th century. This tragedy marked the beginning of rigorous drug approval and monitoring ...

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