Giving the combination of immune checkpoint inhibitors relatlimab and nivolumab to patients with stage III melanoma before surgery was safe and completely cleared all viable tumor in 57% of patients in a Phase II study, researchers ...
Oct 26, 2022
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A new study from the Garvan Institute of Medical Research shows how rises in core body temperature may trigger the inflammatory flares in people with a rare genetic autoinflammatory disease.
Oct 3, 2022
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The advent of small-molecule targeted therapies, a decade ago, revolutionized the treatment of metastatic melanoma, provided that the tumors carry the mutations to respond to these treatments. However, despite a remarkable ...
Sep 22, 2022
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A team of scientists led by Duke-NUS Medical School have identified an important pathway that gets disrupted in the advanced form of non-alcoholic fatty liver disease known as non-alcoholic steatohepatitis (NASH)—and intervening ...
Sep 21, 2022
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Researchers have found the first experimental evidence explaining why the COVID-19 virus produces variants, such as delta and omicron, so quickly.
Sep 14, 2022
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Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food". Building on genetic screens, an international team ...
Sep 9, 2022
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One of the most upsetting aspects of age-related memory decline is not being able to remember the face that accompanies the name of a person you just talked with hours earlier. While researchers don't understand why this ...
Sep 8, 2022
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A new study, published in Frontiers in Molecular Neuroscience, reveals how a rare genetic mutation leads to intellectual disability. The P212L mutation in an enzyme called CaMKIIalpha, which is important for learning and ...
Sep 1, 2022
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Researchers at the Leibniz Institute for Natural Product Research and Infection Biology—Hans Knöll Institute (Leibniz-HKI) in Jena, Germany have identified an enzyme that is a promising new therapeutic target to combat ...
Aug 1, 2022
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A team of researchers affiliated with several institutions in the U.S. and the U.K. has found a link between the APOBEC3A enzyme and the most prevalent mutational signatures in cancer cell lines. In their paper published ...
