During differentiation of pluripotent stem cells to cardiomyocytes, the three-dimensional folding of the DNA reorganizes itself. This reorganization of the DNA architecture precedes and defines important epigenetic patterns. ...
Nov 21, 2017
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How can defective gene activity leading to cancerbe avoided? Researchers at the University of Zurich have now identified a mechanism by which cells pass on the regulation of genetic information through epigenetic modifications. ...
Oct 30, 2017
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We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or lifestyle take a major role in regulating the DNA by switching genes on and off. It has been long debated ...
Jul 14, 2017
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Fathers who use cocaine at the time of conceiving a child may be putting their sons at risk of learning disabilities and memory loss. The findings of the animal study were published online in Molecular Psychiatry by a team ...
Feb 23, 2017
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After the emergence of single-celled organisms some billions of years ago, nature started experimenting with how to diversify gene function without changing the sequence of the DNA, such that the blue print remains conserved, ...
Aug 4, 2016
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A common feature of cancer and aging is cells' reduced ability to respond to stress-induced damage to DNA or cellular structures. Specifically, changes occur in the protective processes of apoptosis and cellular senescence, ...
Jul 13, 2016
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Scientists of the Technical University of Munich (TUM) and the Max Planck Institute of Psychiatry have identified four new risk genes that are altered in German patients with multiple sclerosis (MS). The results point to ...
Jun 20, 2016
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Cancer development is a complex process involving both genetic and epigenetic changes. Genetic changes in oncogenes and tumor-suppressor genes are generally considered as primary causes, since these genes may directly regulate ...
Apr 26, 2016
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I first learned about epigenetics in a "fish bowl" meeting room at the University of Pennsylvania in the summer of 2013, when I worked as a research intern in the Ted Abel lab. We were in the middle of a weekly lab meeting, ...
Mar 14, 2016
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North American researchers have identified drugs that showed promising perspectives in treating cancers, according to a recent study published in Cancer Research. These drugs are normally used to treat other diseases, such ...
Feb 9, 2016
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