Protein NSD2 found to drive early prostate cancer development
Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason that a typically normal protein goes awry and fuels cancer.
Sep 9, 2024
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Researchers at the University of Michigan Health Rogel Cancer Center have uncovered a key reason that a typically normal protein goes awry and fuels cancer.
Sep 9, 2024
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Investigators have discovered that aberrant activation of a specific oncoprotein drives key tumor-promoting changes in the prostate tissue microenvironment during cancer progression, according to a Northwestern Medicine study ...
Aug 29, 2024
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How old are you, really? Your chronological age is the number of years you have been alive. Your biological age is how old your cells are, which scientists believe may better assess one's age-related health and disease risk.
Aug 22, 2024
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In a study published in Cell Chemical Biology, a research team led by Prof. Tan Weihong and Prof. Wu Qin from the Hangzhou Institute of Medical of the Chinese Academy of Sciences has identified protein arginine methyltransferases ...
Sep 6, 2024
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Recent research suggests that epigenetic markers in the blood could be useful for understanding dementia risk. Two linked papers from the University of Exeter and Maastricht University have together progressed research to ...
Aug 28, 2024
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Eating well, exercising and attending regular doctor appointments can support a long healthy life, but a new study identified one possible factor beyond our control: whether you had a grandparent who went to college.
Aug 26, 2024
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Researchers at Weill Cornell Medicine and the epigenetics company TruDiagnostic have uncovered DNA markers associated with retroelements, remnants of ancient viral genetic material in our genes that act as highly accurate ...
Aug 19, 2024
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In the most comprehensive study of its kind, researchers from the Keck School of Medicine of USC compared epigenetic changes across the genome in young adults who vaped, smoked or did not use nicotine products, finding a ...
Aug 13, 2024
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Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) and the German Center for Diabetes Research (DZD) have published a study in Diabetes & Metabolism that sheds light on the molecular adaptations ...
Aug 13, 2024
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In biology, and specifically genetics, epigenetics is the study of heritable changes in gene expression or cellular phenotype caused by mechanisms other than changes in the underlying DNA sequence – hence the name epi- (Greek: επί- over, above, outer) -genetics. Examples of such changes might be DNA methylation or histone deacetylation, both of which serve to suppress gene expression without altering the sequence of the silenced genes. In 2011, it was demonstrated that the methylation of mRNA has a critical role in human energy homeostasis. This opened the field of RNA epigenetics.
These changes may remain through cell divisions for the remainder of the cell's life and may also last for multiple generations. However, there is no change in the underlying DNA sequence of the organism; instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently.
One example of epigenetic changes in eukaryotic biology is the process of cellular differentiation. During morphogenesis, totipotent stem cells become the various pluripotent cell lines of the embryo which in turn become fully differentiated cells. In other words, a single fertilized egg cell – the zygote – changes into the many cell types including neurons, muscle cells, epithelium, endothelium of blood vessels etc. as it continues to divide. It does so by activating some genes while inhibiting others.
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