Oncology & Cancer

Determining risk of recurrence in triple-negative breast cancer

A personalized prognosis for patients diagnosed with triple-negative breast cancer was the goal of a new study by Katherine Varley, Ph.D., researcher at Huntsman Cancer Institute (HCI) and assistant professor of oncological ...

Oncology & Cancer

Estrogen receptors might hold key in obesity prevention

Despite countless fad diets, both obesity and metabolic diseases continue to plague communities across the U.S. Now, researchers from the University of Missouri believe that the clue to treatment might be related to estrogen—for ...

Oncology & Cancer

Oncotype DX not cost-effective for low-risk breast cancer

(HealthDay)—The multigene expression test Oncotype DX (ODX) is not cost-effective for women with breast cancer who are at low risk for recurrence, according to research published online Jan. 22 in the Journal of the National ...

Oncology & Cancer

Rare variants associated with interval breast cancers

(HealthDay)—Though common breast cancer variants indicate increased breast cancer risk, certain rare variants are associated with an increased risk for interval breast cancers and death, according to a study published in ...

Medical research

Hidden estrogen receptors in the breast epithelium

Estrogens are hormones that play central roles in the development and the physiology of the breast, but also are involved in breast cancer. Like all hormones, estrogens exert their biological effects by binding to dedicated ...

page 1 from 22

Estrogen receptor

Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. This article refers to the nuclear hormone receptor ER.

The main function of the estrogen receptor is as a DNA binding transcription factor that regulates gene expression. However, the estrogen receptor has additional functions independent of DNA binding.

This text uses material from Wikipedia, licensed under CC BY-SA